Colombia conceded six goals in a World Cup qualifier for the first time since 1977 as they went down 6-1 to a superb display from Ecuador.
The third round of World Cup qualifying gets underway for Brazil, Argentina, Uruguay and the other CONMEBOL nations. Here's what to watch for.
Argentina got their World Cup qualifying campaign off to the perfect start on Thursday when Lionel Messi's penalty gave them a 1-0 win over Ecuador.
Ecuador international Enner Valencia's sister Erci was rescued by the Ecuadorian security forces on Friday.
Former West Ham forward Enner Valencia's sister has been kidnapped in Ecuador, according to reports confirmed by the Ecuadorian government.
Jordi Cruyff has stepped down as Ecuador coach without leading the national team in any games.
Jordi Cruyff is yet to oversee a match as national team coach, but has already found himself caught up in an institutional crisis in Ecuador.
FIFA is supporting CONMEBOL's request to suspend World Cup qualifiers scheduled for the end of March due to fears over the coronavirus.
Ecuador have hired former Barcelona and Manchester United midfielder Jordi Cruyff as their national team coach.
Ecuador's new head coach has plenty of name recognition, but the amount of work he has to get them to the World Cup should not be underestimated.
Australia will face Lionel Messi and Argentina at next year's Copa America after being drawn in Group A for the South American championship.
Ecuador have denied agreeing terms for Jurgen Klinsmann to become their new national team coach and said media reports are speculation.
Argentina produced one of their best performances in recent times on Sunday with six different scorers in a friendly win over Ecuador.
LAFC have signed defender Diego Palacios from Ecuadorian club SD Aucas using targeted allocation money, the club announced on Monday.
LAFC is set to bring in Ecuadorian left-back Diego Palacios, who had initially drawn interest from La Liga side Barcelona.
The Copa America gave plenty of clues for the 2022 World Cup hopes of winners Brazil, Lionel Messi's Argentina and South America's other nations.
Japan and Ecuador were eliminated from the Copa America on Monday after their 1-1 draw gifted Paraguay a quarterfinal berth.
Chile forward Alexis Sanchez continued his resurgent form at the Copa America by scoring the winning goal in his side's 2-1 victory over Ecuador.
Uruguay made short work of 10-man Ecuador in a 4-0 win to kick off their Copa America campaign atop Group C on Sunday in Belo Horizonte.
Mexico defeated Ecuador 3-2 in an international friendly on Sunday in front of a raucous crowd at AT&T Stadium in Arlington, Texas.
Lionel Messi is determined to win a trophy with Argentina. Is this his summer? We get you ready for a thrilling Copa, all of it live on ESPN+.
Gyasi Zardes scored on deflected shot in the second half to give the United States a 1-0 win over Ecuador on Thursday.
Ecuador's South American Under-20 Championships triumph was a joy to watch. But will that translate to success at a senior level?
The U.S. men's national team will play Ecuador in an exhibition on March 21 at Orlando City Stadium.