The Eagles (2-1) led 35-14 after Hamilton's 10-yard run early in the fourth quarter. Bryant added a 54-yard TD pass to Zach Westmoreland to make it 42-21 with just over four minutes remaining.
David Carter's interception, his second in two weeks, set up a nine-play drive that ended with Samson Evans scoring from 13 yards out for a 21-0 lead before the Minutemen got their first points on Josiah Johnson's 1-yard run that completed an 80-yard drive to trail 21-7 at the break.
Hutchinson and Boone had TD runs to complete a pair of first-quarter Eastern Michigan drives for a 14-0 lead.
Brady Olson threw for 288 yards including TD passes of 45 yards to Melvin Hill and a 29-yarder to Johnson along with an interception. Ellis Merriweather rushed for a career-high 142 yards on 23 carries and Carter Scudo ran for a 2-yard TD for UMass.
The teams combined for more than 1,000 yards offense.
The Minutemen (0-3) have lost 14 straight games dating back to 2019.
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