Giant Killers: Midwest upset picks

John Thompson III's Hoyas have fallen prey to early upsets before. Jim McIsaac/Getty Images

As we promised in the Giant Killers blog, on Monday we began detailed breakdowns of all the round of 64 games with GK implications.

Now that we all have brackets in hand, it's time for a detailed look at how our Giant Killers statistical model sees NCAA tournament matchups. We'll go region by region, and, as we did in 2011, we will sort potential upsets into four categories: Best Bets, Worth a Long Look, Not Completely Crazy and Stay Away. These names should be pretty self-explanatory -- Best Bets have a decent chance to win outright, and Stay Aways are likely to lose no matter what. But we can't tell you exactly how to fill out your brackets because that depends on how heavily your particular pool rewards upsets. The more points you score when underdogs win, the more you should be willing to pick high-risk teams.

In case you've forgotten, a Giant Killer is a team that beats an opponent seeded at least five spots better and doesn't come from a BCS conference. Other teams -- Gonzaga, Butler, BYU, Temple and Xavier -- are excluded because of their historical success. (Check out our methodology for a full explanation.) Our model generates statistical ratings that compare potential Giant Killers to past Davids as well as all Giants to the Goliaths who were slain. Those ratings enable us to predict the chances of an upset in each matchup.

We continue in the Midwest, the lightest region in terms of Giant Killers matchups. But there appears to be one juicy upset just waiting to happen.

Upset picks in the South | East | West | Midwest