Adesanya hurt Pereira at the end of Round 1 and then dominated the ground game in the third before Pereira took over in the final round, forcing referee Marc Goddard to stop the fight after landing a flurry of punches on Adesanya.
So, now what? Is a rematch in play? What other options does Pereira have?
Dustin Poirier and Michael Chandler put on a fight to remember, with Poirier stopping Chandler in Round 3 with a rear-naked choke of their bloody lightweight bout. Should a title fight be next for Poirier? How about Chandler? Where does he go from here?
Dan Hooker was only 1-4 entering the fight, but his second-round TKO victory over Claudio Puelles put him back into the conversation for a bigger fight early next year. Same for flyweight Erin Blanchfield after dominating Molly McCann. A fight against Maycee Barber could be a must-see if they fight next.
Brett Okamoto shares his thoughts on what fights could be ahead in 2023 for some of the stars at UFC 281.
Alex Pereira, middleweight champion (defeated Israel Adesanya by fifth-round TKO to win the title)
Who should be next: rematch
I'm calling it the second fight between these two, not the fourth. They fought in kickboxing, a different sport, and they were just two totally different versions of themselves. They've both matured so much from those fights. In terms of their rivalry, this was the best chapter and the most complete versions of themselves. They have to run it back. Adesanya had essentially cleaned out the division before this, and he's deserving of an immediate rematch. Seems obvious.
Wild card: Robert Whittaker
If Whittaker beats Paulo Costa at UFC 284 on Feb. 11, I could see the shot going to him. I'd have to see what Adesanya wants to do -- when he wants to fight next. And what the UFC wants to do. I'd include Costa in this looking ahead, but he's made it pretty clear he's leaving the UFC, win or lose, after Whittaker. If he wants to rethink that, he'd be in this mix. I'm sure though Whittaker watched some of the wrestling exchanges of this fight and was licking his lips.
Zhang Weili, women's strawweight champion (defeated Carla Esparza by second-round submission to win the title)
Zhang Weili forces Carla Esparza to tap to reclaim her strawweight title in the co-main event of UFC 281.
Who should be next: Rose Namajunas
It feels like we're recycling the same title fights in this division, but the circumstances have called for it. And for the most part, the fights have been incredibly well-matched. This has been an entertaining division in recent years. It doesn't feel right to ask Zhang to go straight into a title defense against a woman she has fought twice (and lost to twice) in the last 1.5 years, but if we're stating facts, it's the correct fight to make. Namajunas lost the title to Esparza in a bizarre fight that could have gone either way. Namajunas-Zhang 2 was close, so a trilogy bout makes sense for just about every reason you can think of.
Wild card: Amanda Lemos
If the UFC (or Zhang) really wants to do something different, Lemos is a strong option. She has one-punch knockout power and is coming off a win in a UFC Fight Night main event against Marina Rodriguez, an opponent who had built up a lot of momentum before the fight.
Dustin Poirier, lightweight (defeated Michael Chandler by third-round submission
Dustin Poirier and Michael Chandler trade blows in an incredible first round of their fight.
This felt obvious coming into the week for me -- that if Poirier won, his next move would be a title shot. Why wouldn't it be? He was the No. 2 ranked contender in the division coming into this matchup, behind only Charles Oliveira, who just lost to Makhachev. He's still a name, less than a calendar year removed from beating Conor McGregor -- twice. And this performance against Chandler will only raise his stock. Poirier deserves the opportunity and matches up fine with either option. It gets tricky if Volkanovski wins, because Volkanovski would likely go back down to 145 pounds to defend his featherweight title, but Makhachev vs. Poirier is a fine title fight.
Wild card: Rafael Fiziev
The UFC has been looking at Fiziev vs. Justin Gaethje, but if that doesn't come together, Fiziev vs. Poirier is a terrific fight. On its surface, it's hard to see why Poirier would take this fight. It's essentially all risk. But Poirier is a madman who likes to fight frequently. He doesn't like extended time off. If he's down for it, it's a good one.
Michael Chandler, lightweight (lost to Dustin Poirier by third-round submission
Who should be next: Conor McGregor
How many times have we brought this up? Chandler has fought in the UFC five times, and we've said it all five times. Chandler is on a short list for the most entertaining fighters in MMA. He is all gas, from the first bell. He knows how to build a fight. Chandler vs. McGregor, it's a perfect fight. Exactly when McGregor will ever fight again, if ever, we'll never know. But once again, Chandler is coming off a situation where he'll probably need some time off after taking damage on Saturday. There's no Nate Diaz in the UFC (at least at the moment) for McGregor to come back to. McGregor vs. Chandler sells, but again, we've said that before.
Wild card: wait?
Chandler needs some pieces to reset before we know what's next for him. Unfortunately, that's sometimes the case when you're a big name, but not stringing together enough wins. If he does want to come back, he might have to fight down the rankings. A rising contender in need of a higher ranked fight.
Chris Gutierrez, bantamweight (defeated Frankie Edgar first-round knockout)
Who should be next: Pedro Munhoz
This was Frankie Edgar's last fight and in those situations, sometimes the winner gets credit and sometimes they don't. Sometimes we chalk up the win to their opponent having one foot out the door. In this case, it's both. Everyone would agree it was probably the right time for Edgar to end his legendary career, but most would agree Gutierrez looked impressive with his performance. He's a growing force in this division. It's time to book him against a name in the rankings who needs to defend his spot. And that's Munhoz. That was basically the situation Munhoz was in for his last fight against Sean O'Malley, and that ended in a no-contest. So, book him a similar fight.
Wild card: Adrian Yanez
If you want to have some fun, we could do two more intriguing rising contenders and strikers at bantamweight against one another. And you know what? You could make this a main event. These two aren't of the usual name value you'd see in a main event, but sometimes the UFC can decide to tell people what to care about, and giving these two that kind of promotional rub might be a brilliant thing.
Dan Hooker, lightweight (defeated Claudio Puelles by second-round TKO)
Who should be next: Jalin Turner
Hooker wants to fight at UFC 284 in Australia, and you know the UFC will oblige. Expect him on that card in a big spot. He's very popular in the region. If you're the UFC, you want to use that attention wisely and pair Hooker in a fun fight where the UFC will benefit however it goes. That's what makes Turner perfect. If Turner wins, he's a surging contender who is adding a big name to his résumé. If Hooker wins, it'll likely be in a fun fight, and resolidify him as a serious name at 155. Turner has won five contests in a row, and wouldn't you know it, his last one was against Hooker's teammate, Brad Riddell.
Wild card: Renato Moicano
Moicano also gave a great performance on Saturday, which also happened to come at Riddell's expense. Moicano isn't ranked and Hooker deserves that, but honestly, the number isn't important for Hooker's fight now. A quality fight that people want to see should be the goal. And this would qualify.
Erin Blanchfield, flyweight (defeated Molly McCann by first-round submission)
Erin Blanchfield stuns the Madison Square Garden crowd by forcing Molly McCann to tap out.
Who should be next: Maycee Barber
No exaggeration, Blanchfield just became must watch with this win. It's not just that she beat McCann, or even that she dominated her -- it was just the clear, evident skill she showed in doing so. Everything from the level change on the takedown, positional advancement, control and composure, Blanchfield's skill set is scary. And she's only 23.
In some ways, she is who we thought Barber would be, and still can be. Barber is also a super talent at a very young age. I don't like the idea of pairing them early in their careers, but the storyline is great and would build the winner. Barber said she was at the end of her UFC contract in July, so we'll need clarity that. But this could be the one.
Wild card: Andrea Lee
To be frank, this is a style matchup that would probably favor Blanchfield on paper. But it would test her against someone with dangerous striking and a lot of experience. And also, the rankings say this one makes perfect sense. Lee is No. 9 at the moment.