These two teams last met in January's NFC title game, where the 49ers fell 20-17 to the eventual Super Bowl champs. Despite that victory, the team has struggled in recent years against San Francisco. The Rams have recorded seven consecutive regular-season losses against the 49ers -- and five of those have been decided by one score.
Here are some of the best ManningCast moments from Week 4:
MNF to SNL
Hamm has now been a guest on both shows.
Peyton broke down Bobby Wagner's tackle on a fan who ran on the field.
Von Miller may need to reassess his evaluation of Steph's playing style.
Hurts, the NFC MVP of the month, has been in the end zone fairly often this season, so he's had plenty of time to work on his dance moves. According to Eli, Peyton can relate.
"Natural" is a loose term pic.twitter.com/FH8QkhngON— Omaha Productions (@OmahaProd) October 4, 2022
Peyton was in familiar territory with his wristband.
Peyton is in his element calling plays from the wristband pic.twitter.com/9euDrsWboN— Omaha Productions (@OmahaProd) October 4, 2022
Eli brought on an unofficial special guest for the night.