ESPN+ will be the home of the Bundesliga in the United States with live games on ESPN networks, as well as live streams of the DFL Supercup and relegation playoff matches.
Bayern will face the Europa League winners on Aug. 5 as they look to retain the league title for a record-extending 11th time in a row.
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No team had won more than three consecutive Bundesligas before Bayern's stunning run and coach Julian Nagelsmann will be hoping to secure back-to-back titles in his time in charge.
It is a new era at the club with Edin Terzic starting his first full campaign in charge after replacing Marco Rose while Dortmund will also be without star striker Erling Haaland who completed a move to Manchester City.
It won't be an easy start for Dortmund who face a Leverkusen side that finished five points behind them in third position last season.
Meanwhile, RB Leipzig travel to Stuttgart on the opening weekend of the campaign, while promoted sides Schalke and Werder Bremen face tough away trips at Cologne and Wolfsburg respectively.
There will also be an opening weekend derby between Union Berlin and Hertha BSC, while Cologne welcome Schalke and Borussia Monchengladbach host Hoffenheim.
Dortmund will host Bayern in the first Der Klassiker of the new season on Oct. 8 at Signal Iduna Park.
Bundesliga opening weekend fixtures:
Saturday, Aug. 16 or Sunday, Aug. 17
Borussia Dortmund vs. Bayer Leverkusen
Union Berlin vs. Hertha Berlin
FC Cologne vs. Schalke 04
Borussia Monchengladbach vs. TSG Hoffenheim
VfL Wolfsburg vs. Werder Bremen
VfL Bochum vs. Mainz
FC Augsburg vs. SC Freiburg
VfB Stuttgart vs. RB Leipzig