Newly-crowned MLS Cup champions LAFC will play Costa Rica's Alajuelense in the 2023 CONCACAF Champions League Round of 16.
Both MLS and Liga MX will pause next summer to take part in the interleague Leagues Cup 2023.
CONCACAF has unveiled the qualification criteria for the confederation's expanded Champions League starting in 2024.
It had been more than 20 years since an MLS side could claim continental supremacy, but now the Seattle Sounders can after beating Pumas.
Seattle Sounders FC beat Pumas UNAM 3-0 with Raul Ruidiaz double to win CONCACAF Champions League final.
Seattle Sounders manager Brian Schmetzer said it would be "a huge honor" if the Sounders can beat UNAM Pumas in the second leg of the CCL final.
No MLS team has ever won the CONCACAF Champions League. That could change Wednesday, when a well-funded Seattle side hosts Mexico's Pumas.
Nicolas Lodeiro converted two second-half penalties to lift the Seattle Sounders to a 2-2 draw against Pumas in the first leg of the CCL final.
MLS has ambitions of being among the best in the world, but that can't happen until it can best the league in the country it shares a border with.
Seattle Sounders advanced to the CONCACAF Champions League final for the first time in club history after a draw on Wednesday against NYCFC.
Pumas UNAM played to a scoreless draw against Cruz Azul on Tuesday night to advance 2-1 on aggregate to the CONCACAF Champions League final.
Jordan Morris set up one first-half goal and scored another, helping the Seattle Sounders beat NYCFC 3-1 in Wednesday's CCL semifinal first leg.
Juan Ignacio Dinenno's two first-half goals led Pumas to a 2-1 win over Cruz Azul in Tuesday's CONCACAF Champions League semifinal first leg.
Pumas star Sebastian Saucedo, a dual-national who played for the U.S. at the youth level, talks about Liga MX and if he is open to a Mexico switch.
Seattle Sounders advanced to the semifinals of the CONCACAF Champions League after a 4-1 aggregate victory over Leon.
Pumas pulled off a stunning comeback to beat the New England Revolution in the CONCACAF Champions League quarterfinals on Wednesday in Mexico City.
Uriel Antuna scored again to lead Cruz Azul past host CF Montreal in the finale of a quarterfinal CONCACAF Champions League series on Wednesday.
New York City FC advanced to the CONCACAF Champions League semifinals despite a 4-2 loss to Comunicaciones FC on Tuesday in Guatemala City.
Uriel Antuna gave Cruz Azul a 1-0 victory over CF Montreal in Mexico City in the opening leg of a CONCACAF Champions League quarterfinals series.
The New England Revolution routed Pumas 3-0 on Wednesday in Foxborough, Mass., in the first leg of a CONCACAF Champions League quarterfinal series.
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