Second-bottom Parma looked to be in with a chance of earning three priceless points in their relegation battle when Gaston Brugman fired a low free kick into the net in the 25th minute to give the visitors a shock lead.
Yet a double from full-back Alex Sandro turned the match on its head either side of halftime, with another defender -- Matthijs de Ligt -- heading a third in the 68th minute to put the game to bed.
On a tumultuous day at the club, following their withdrawal from the proposed European Super League, Juve must have thought the world was against them as Brugman's free kick somehow squirmed under the wall and into the net.
Even with top goalscorer Cristiano Ronaldo back in the side, Juve struggled to make any immediate response.
Brazilian Sandro, however, fired a superb left-footed strike into the net just before the break and then headed home less than two minutes into the second half to complete the turnaround.
De Ligt's equally well-taken header put the seal on the win to help Juve close to within one point of AC Milan in second.