Marseille, who brought on new signing Alexis Sanchez at half-time for his debut, were ahead after 38 minutes as another newcomer, Nuno Tavares, scored with a header, but Pierre Lees-Melou's equaliser was reward for Brest who might well have gone on to win the match.
Toulouse enjoyed their first win back in Ligue 1 after promotion with a 3-0 victory at Troyes while Racing Lens drew away at Ajaccio earlier on Sunday.
Clermont came from two goals down to beat Stade Reims 4-2 and leave them bottom of the French league standings.
Auxerre, back in the top flight after a decade's absence, were 2-0 up in 10 minutes against Angers through Julian Jeanvier and a Cedric Hountondji own goal but let their chance of a first win of the campaign slip as Lois Diony reduced the deficit and then, after Lassine Sinayoko was sent off, Amine Salama equalised 13 minutes from time.
Komnen Andric netted a double for Clermont with a penalty and an unchallenged header to level the scores just past the hour and then new Austrian signing Muhammed-Cham Saracevic and Jeremie Bela completed the turnaround. Saif-Eddine Khaoui might have made it 5-2 in the last three minutes but had his strike disallowed for offside.
Toulouse continued their good start to the season by winning at Troyes, where Yasser Larouci scored a 36th-minute own goal to put the visitors into the lead and Rafael Ratao and Rhys Healey added second-half goals.