Zalgiris Vilnius ZALG 1 - 1 |  Bodo/Glimt BODO | FT | LFF Stadionas, Vilnius, Lithuania | 5,067 |
| Bodo/Glimt win 6-1 on aggregate |
Apollon Limassol APL 2 - 0 |  Maccabi Haifa HAI | FT | GSP Stadium, Nicosia, Cyprus | 3,936 |
| Maccabi Haifa win 4-2 on aggregate |
Pyunik PYU 0 - 2 |  Red Star Belgrade RSB | FT | Vazgen Sargsyan Republican Stadium, Yerevan, Armenia | 6,000 |
| Red Star Belgrade win 7-0 on aggregate |
Viktoria Plzen PLZ 2 - 1 |  Sheriff Tiraspol SHE | FT | Doosan Arena, Plzen, Czech Republic | 10,770 |
| Viktoria Plzen win 4-2 on aggregate |
FC Midtjylland MIDT 1 - 3 |  Benfica BEN | FT | Cepheus Park Randers, Randers, Denmark | 5,111 |
| Benfica win 7-2 on aggregate |
Dinamo Zagreb ZAG 4 - 2 |  Ludogorets Razgrad LUD | FT | Maksimir, Zagreb, Croatia | 13,658 |
| Dinamo Zagreb win 6-3 on aggregate |
Ferencvaros FER 1 - 3 |  FK Qarabag FKQA | FT | Groupama Arena, Budapest, Hungary | 18,875 |
| FK Qarabag win 4-2 on aggregate |
PSV Eindhoven PSV 3 - 2 |  AS Monaco MON | AET | Philips Stadion, Eindhoven, Netherlands | 35,000 |
| PSV Eindhoven win 4-3 on aggregate |
SK Sturm Graz STG 1 - 2 |  Dynamo Kyiv KYIV | AET | Merkur Arena, Graz, Austria | 14,007 |
| Dynamo Kyiv win 3-1 on aggregate |
Rangers RAN 3 - 0 |  Union St.-Gilloise USG | FT | Ibrox Stadium, Glasgow, Scotland | 48,454 |
| Rangers win 3-2 on aggregate |
