The winger also suffered ligament damage in his left ankle.
The LaLiga club announced Corona will undergo surgery on Thursday and is expected to be out of action between four and five months.
"He has suffered a major injury in training," Sevilla said in a statement.
"Tests have revealed that he suffers from a fractured fibula and deltoid ligament in his left ankle."
Sevilla coach Julen Lopetegui had feared Corona's injury was serious.
Speaking ahead of Friday's league clash against Almeira, Lopetegui said: "Tecatito got injured this morning.
"It doesn't look good. He was taken by ambulance and I hope it's not serious, but I insist, it doesn't look good."
Corona, 29, has scored 10 goals in 71 appearances for Mexico since making his national team debut in 2014.